Long-term sequelae of hearing impairment in congenital hypothyroidism

J Rovet1, W Walker, B Bliss

  • 1Department of Psychology and Communication Disorders, Hospital for Sick Children, Toronto, Ontario, Canada.

Insights

Congenital hypothyroidism in children can lead to significant hearing loss, impacting speech and reading skills. Early treatment onset is crucial for mitigating these developmental effects.

Area of Science:

  • Pediatrics
  • Audiology
  • Endocrinology

Background:

  • Congenital hypothyroidism (CH) is a condition detectable through newborn screening.
  • Hearing impairment is a potential complication of CH, affecting child development.

Purpose of the Study:

  • To evaluate hearing loss and its functional consequences in children with CH.
  • To assess the impact of hearing impairment on language and reading abilities in this cohort.

Main Methods:

  • Retrospective analysis of 101 children with CH, with hearing tests on 75.
  • Audiological assessments, language, and auditory processing evaluations at ages 3, 5, and 7.
  • Comparison of reading skills at grade 3 between hearing-impaired children, normally hearing children with CH, and matched controls.

Main Results:

  • 15% of children with CH experienced hearing problems, including sensorineural and conductive loss.
  • Hearing-impaired children had a delayed age of treatment onset (22 vs. 14 days).
  • Deficits in early speech, receptive language, auditory discrimination, and phonologic processing skills were observed in hearing-impaired children, affecting reading ability.

Conclusions:

  • Hearing loss is a significant concern in children with CH, often linked to delayed treatment.
  • Functional consequences include persistent language and auditory processing deficits, leading to poorer reading skills.
  • Early detection and intervention for hearing issues in CH are critical for optimal developmental outcomes.

Related Concept Videos

Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
Goiter01:27

Goiter

Goiter refers to an abnormal enlargement of the thyroid gland that may appear as a diffuse goiter (uniform enlargement) or nodular (single or multiple nodules). Functionally, it is classified as nontoxic (normal/low hormone levels) or toxic (excess hormone production).PathophysiologyDiffuse thyroid enlargement typically results from prolonged stimulation by thyroid-stimulating hormone (TSH) or TSH-like agents, commonly seen in hypothyroidism or iodine deficiency. In contrast, in hyperthyroid...
Hypothyroidism II: Pathophysiology01:23

Hypothyroidism II: Pathophysiology

Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...