[Study on cephaloridine concentration in bone marrow (author's transl)]

Area of Science:

• Pharmacokinetics
• Antibiotic Research
• Bone Marrow Penetration

Context:

• Understanding antibiotic distribution is crucial for treating bone infections.
• Cephaloridine (CER) is an antibiotic with potential applications in bone infections.
• Limited data exists on CER penetration into bone marrow.

Purpose:

• To quantify Cephaloridine (CER) concentration in tibial bone marrow.
• To assess the penetration capacity of CER into bone marrow.
• To compare CER concentrations in bone marrow versus serum over time.

Summary:

• CER concentrations were measured in tibial bone marrow at 1, 2, and 3 hours post-intramuscular injection (1g).
• Bone marrow CER levels were consistently high, ranging from 26.0 to 14.8 µg/ml.
• The ratio of bone marrow to serum CER concentration increased over time, reaching 91.9% at 3 hours, with no significant difference observed.

Impact:

• Findings suggest excellent penetration of CER into tibial bone marrow.
• Results support the potential efficacy of CER for treating bone infections.
• This study provides valuable pharmacokinetic data for CER in bone tissue.