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Transperineal photodynamic ablation of the canine prostate
S H Selman1, R W Keck, J A Hampton
1Department of Urology, Medical College of Ohio, Toledo 43699-0008, USA.
Purpose:
Experiments were undertaken to determine the effects of transperineal interstitial photodynamic therapy on the canine prostate.
Materials And Methods:
Mongrel dogs were injected intravenously with the photosensitizer, tin (II) ethyl etiopurpurin dichloride. Twenty-four hours later, 2 optical fibers were implanted in 1 hemisphere of the prostate, which was then treated with red light (660 nm.).
Results:
Acutely, the treated areas showed extensive hemorrhagic necrosis. At 3 and 6 weeks, the treated lobes were largely replaced by fibrous connective tissue.
Conclusion:
Transperineal photodynamic therapy of the canine prostate is feasible. Further preclinical investigation is warranted to determine the applicability of this approach to the treatment of localized prostate cancer.