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Early pathologic and biochemical changes in Creutzfeldt-Jakob disease: study of brain biopsies
R Castellani1, P Parchi, J Stahl
1Institute of Pathology, Division of Neuropathology, Cleveland, OH 44106, USA.
Neurology
|June 1, 1996
Abstract:
We examined brain biopsy tissue from five patients with a neurologic syndrome consistent with Creutzfeldt-Jakob disease using Western blot analysis and immunohistochemistry for the detection of protease-resistant prion protein, in addition to histopathologic examination. Our results indicate that the formation of protease-resistant prion protein is an early event in disease pathogenesis and Western blot analysis can detect protease-resistant prion protein in the absence of structural lesions using a small amount of brain biopsy tissue.