[Diagnosis and treatment of Cushing's disease]

Authors present the results of surgical treatment of 63 patients with Cushing's disease. They evaluate various diagnostic procedures, applied to define the aetiology of endogenous hypercortisol. The petrosal sinus sampling for ACTH level is described. In the series in only 32% of patients; radiological examinations (including CT and MRI) showed the pituitary adenoma. Among 63 operated persons--43 were subjected to surgery based on endocrinological data alone. All the patients were operated by transsphenoidal route. Good result--endocrinological recovery in the treatment of Cushing's disease was achieved in 80% of patients.