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The aging process. Physiologic changes and pharmacologic implications

J A Troncale1

  • 1Lancaster General Hospital, PA 17604, USA. drjat@epix.net

Postgraduate Medicine
|May 1, 1996
PubMed
Summary

Physiologic changes with aging impact medical decisions, affecting functional reserve and drug responses. Understanding homeostenosis in older adults enhances care and quality of life.

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Area of Science:

  • Gerontology
  • Physiology
  • Internal Medicine

Background:

  • Aging involves progressive physiologic alterations affecting organ systems starting from the fifth decade.
  • These changes reduce functional reserve, increasing vulnerability to illness and stress.
  • Physicians must recognize the implications of aging on diagnostics and therapeutics.

Purpose of the Study:

  • To highlight the importance of age-related physiologic changes in clinical decision-making.
  • To introduce and explain the concept of homeostenosis in the context of aging.
  • To emphasize the benefits of applying the homeostenosis concept to patient care.

Main Methods:

  • Review of age-related physiologic changes.
  • Explanation of the concept of homeostenosis.
  • Discussion of clinical implications for elderly patients.

Main Results:

  • Age-related changes begin in the fifth decade and vary by organ system.
  • Decreased functional reserve and altered drug actions are key considerations.
  • Homeostenosis describes the increased vulnerability of older adults due to reduced reserve.

Conclusions:

  • Awareness of aging's physiologic impact is crucial for effective medical practice.
  • The concept of homeostenosis provides a framework for understanding elderly vulnerability.
  • Clinical application of homeostenosis improves medical outcomes and enhances quality of life for older patients.

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