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Fibrinolysis in human peritoneum during operation
L Holmdahl1, E Eriksson, M al-Jabreen
1Department of Surgery, Ostra Hospital, University of Göteborg, Sweden.
Surgery
|June 1, 1996
Summary
Peritoneal fibrinolytic capacity, mainly from tissue-type plasminogen activator (t-PA), is significantly reduced during peritonitis and operation. This diminished fibrinolytic activity may contribute to adhesion formation in inflamed peritoneum.
Area of Science:
- Peritoneal physiology
- Fibrinolysis research
- Inflammation mechanisms
Background:
- Reduced local fibrinolysis is implicated in adhesion formation.
- Peritonitis is a known cause of adhesions.
- Understanding peritoneal fibrinolytic capacity is crucial.
Purpose of the Study:
- To determine peritoneal fibrinolytic capacity in inflamed and normal peritoneum.
- To investigate the role of plasminogen activator activity (PAA) in peritonitis-associated adhesions.
Main Methods:
- Biopsy specimens of normal and inflamed human peritoneum were collected intraoperatively.
- Plasminogen activator activity (PAA) was measured using a chromogenic substrate assay.
- Inhibitory antibodies against t-PA, urokinase, and PAI-1 were used to characterize PAA.
Main Results:
- Tissue-type plasminogen activator (t-PA) accounted for 95% of the measured PAA.
- PAA was significantly lower in peritonitis compared to normal peritoneum (p < 0.01).
- PAA decreased significantly during operation in both normal and inflamed peritoneum (p < 0.05).
Conclusions:
- The primary source of PAA in the human peritoneum is t-PA.
- Peritoneal PAA decreases during surgical procedures and is reduced in the presence of peritonitis.
- This reduction in fibrinolytic activity may represent a local response to peritoneal inflammation.