Toxic effects of grass carp, snake and chicken bile juices in rats

To evaluate the toxic effects of different animal bile juices, male Long-Evans rats were used and treated orally with different doses (0.03-0.6 ml) of grass carp, snake and chicken bile juices. After treating with one high dose (0.6 ml) for 6 and 24 h, the levels of glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), alkaline phosphatase (ALP), blood urea nitrogen (BUN) and creatinine in the plasma of rats in the grass carp bile juice group became higher than those of the other two bile treated groups. After 3-days periodic treatment with 0.3 ml of each animal bile juice for 28 days, the levels of GOT, GPT, BUN and creatinine in the plasma of rats were significantly increased, especially the grass carp bile juice-treated rats. It appeared that the rats administered with snake and chicken bile juices for a much longer time were poisoned and had the same symptoms as those treated with grass carp bile juice.