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[Optic neuritis and vitamin C]

Y Ichibe1, S Ishikawa

  • 1Department of Ophthalmology, School of Medicine, Kitasato University, Kanagawa, Japan.

Nippon Ganka Gakkai Zasshi
|May 1, 1996
PubMed
Summary

High-dose intravenous vitamin C effectively treats optic neuritis (ON), improving vision comparable to other treatments. This study found vitamin C deficiency in ON patients, suggesting it as a potential treatment of choice.

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Area of Science:

  • Neurology
  • Ophthalmology
  • Nutritional Science

Context:

  • Optic neuritis (ON) is an inflammatory condition affecting the optic nerve, often of unknown cause.
  • Patients with ON frequently exhibit deficiencies in certain vitamins and minerals.
  • Current treatments for ON include corticosteroids, with varying efficacy and side effect profiles.

Purpose:

  • To investigate the efficacy of high-dose intravenous vitamin C in treating optic neuritis (ON) of unknown etiology.
  • To compare the visual recovery outcomes of intravenous vitamin C with other standard treatments for ON.
  • To assess blood nutrient levels in ON patients and correlate them with treatment response.

Summary:

  • Twenty-five patients with optic neuritis received high-dose intravenous vitamin C. Blood levels revealed significant deficiencies in vitamin C, vitamin E, vitamin B6, and zinc.
  • Visual recovery, including amplitude, time to maximum vision, and speed, was analyzed and compared to groups receiving intravenous corticosterone, oral corticosterone, or oral vitamin B12.
  • All treatment groups showed significant vision improvement, with no statistically significant difference in visual acuity gains between groups. Intravenous vitamin C demonstrated comparable efficacy.

Impact:

  • Intravenous vitamin C administration emerges as a viable and potentially preferred treatment option for optic neuritis, offering comparable visual recovery to corticosteroids.
  • The findings suggest a potential role for vitamin C in managing optic neuritis, possibly through antioxidant mechanisms.
  • Further research into the specific mechanisms of vitamin C action in optic neuritis is warranted.

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