Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Selective renal transplantation in primary hyperoxaluria type 1

A R Allen1, E M Thompson, G Williams

  • 1Renal Unit, Department of Medicine, Royal Postgraduate Medical School, London, United Kingdom.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|June 1, 1996
PubMed
Summary

Primary hyperoxaluria type I (PHI) causes kidney failure due to low alanine:glyoxylate aminotransferase (AGT) activity. Isolated kidney transplants may now be feasible for select PHI patients with residual AGT activity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chronic kidney disease mediates cardiac dysfunction associated with increased resident cardiac macrophages.

BMC nephrology·2022
Same author

Development of polymorphic markers in the immune gene complex loci of cattle.

Journal of dairy science·2021
Same author

An international patient-centred study of retroperitoneal fibrosis.

QJM : monthly journal of the Association of Physicians·2020
Same author

Prognostic Importance of Pathological Fractures in Osteosarcomas.

Irish medical journal·2020
Same author

Corrigendum: Bovine Tuberculosis in Britain and Ireland - A Perfect Storm? the Confluence of Potential Ecological and Epidemiological Impediments to Controlling a Chronic Infectious Disease.

Frontiers in veterinary science·2019
Same author

IgG4-related disease in a multi-ethnic community: clinical characteristics and association with malignancy.

QJM : monthly journal of the Association of Physicians·2019

Area of Science:

  • Nephrology
  • Metabolic Disorders
  • Genetics

Background:

  • Primary hyperoxaluria type I (PHI) is a genetic disorder leading to end-stage renal disease in young individuals.
  • It stems from deficient hepatic peroxisomal alanine:glyoxylate aminotransferase (AGT) activity, causing hyperoxalemia and hyperoxaluria.
  • This results in kidney stones, nephrocalcinosis, renal impairment, and systemic oxalosis, historically leading to poor outcomes with isolated renal transplants due to graft oxalosis.

Related Experiment Videos