[Protective effect in mice of the live rabies vaccine produced using the Göttingen bioreactor]

For the control of urban rabies in developing countries, the SAD-virusstrain was used in the Göttingen two-step Bioreactorsystem as a model-virus for oral vaccine production. The quality of the antigen had been tested by challenge. In the Bioreactorsystem, controlled by computer, a high standard of cell quality and cell density up to 6 x 10(6) cells/ml had been maintained. The high cell quality is correlated to high proliferation of rabies virus. Virus titres up to 10(8.5) pfu/ml were reached. The protectivity of the antigen had been tested by challenge. In comparison to a commercial vaccine with a PD50 of 10(-1.92) the SAD-Antigen of the Göttingen Bioreactorsystem reached a PD50 of 10(-1.63) by a challenge doses of 70-75 MLD50.