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Peroxisome proliferators activate cytochrome P450 genes in an alkane-assimilating yeast, Candida maltosa
R Ohtomo1, K Kobayashi, S Muraoka
1Department of Biotechnology, University of Tokyo, Japan.
Biochemical and Biophysical Research Communications
|May 24, 1996
Abstract:
Candida maltosa can assimilate n-alkane as a sole carbon source and cytochromes P450ALK (P450ALK) are critical for the first oxidation step. Four major P450ALKs that are encoded by genes ALK1, ALK2, ALK3 and ALK5 are induced by n-alkane and repressed by glucose at the transcriptional level. In the present work, we found that all these four genes but ALK5 are transcriptionally activated in response to a peroxisome proliferator, clofibrate. This is the first report on the peroxisome proliferator responsive gene expression in lower eucaryotes.