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Related Experiment Videos

[Alveolar sarcoma. Report of a case]

L Devisme1, E Mensier, S Bisiau

  • 1Service d'Anatomie et Cytologie Pathologiques, Hôpital Calmette, CHRU, Lille.

Annales De Pathologie
|January 1, 1996
PubMed
Summary

This report details an unusual case of primary pulmonary alveolar soft part sarcoma in a 39-year-old woman. The study highlights the tumor's microscopic features and immunohistochemical profile, contributing to understanding this rare condition.

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Area of Science:

  • Oncology
  • Pathology
  • Rare Cancers

Background:

  • Alveolar soft part sarcoma (ASPS) typically originates in deep soft tissues.
  • Primary pulmonary ASPS is exceptionally rare, with few documented cases.

Observation:

  • A 39-year-old woman presented with thoracic pain, leading to the discovery of a primary pulmonary tumor.
  • Surgical resection of the left lower lobe was performed.
  • Microscopic examination revealed the characteristic alveolar pattern and PAS-positive crystals of ASPS.

Findings:

  • Immunohistochemistry showed granular cytoplasmic reactivity for vimentin, myoglobin, methionine-enkephalin, S100 protein, and neuron-specific enolase.
  • Electron microscopy confirmed the presence of numerous crystallized structures within tumor cell cytoplasm.

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  • This represents the third reported case of pulmonary ASPS, with one originating from the pulmonary vein.
  • Implications:

    • The histogenesis of ASPS remains unclear, with ongoing debate regarding its myogenic or neural origin.
    • This case adds to the limited literature on pulmonary ASPS, providing further data for analysis.
    • Further research is needed to elucidate the origins and optimal treatment strategies for this rare sarcoma.