Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A pyrazoline derivative of eunicin acetate

S Khalil1, M B Hossain, D van der Helm

  • 1Department of Chemistry and Biochemistry, University of Oklahoma, Norman 73019, USA.

Acta Crystallographica. Section C, Crystal Structure Communications
|May 15, 1996
PubMed
Summary

This study determined the crystal structure of a novel pyrazoline derivative of eunicin acetate. The spiro substitution altered bond lengths and molecular geometry within the cembranolide skeleton.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Management of cutaneous squamous cell carcinoma: A literature review and update.

Journal of the American Academy of Dermatology·2025
Same author

Role of Macular Ganglion Cell Complex Analysis for Diagnosis of Glaucoma Using Spectral Domain Optical Coherence Tomography.

Mymensingh medical journal : MMJ·2025
Same author

Repeated HLA-DRB1 and HLA-DQB1 Mismatches Without Preformed DSA Affect Graft Survival, Rejection and DSA Development: A Multicenter Analysis.

HLA·2025
Same author

Corrigendum to "Two decades of continuous progresses and breakthroughs in the field of bioactive ceramics and glasses driven by CICECO-hub scientists" [Bioact. Mater. 40 (2024) 104-147].

Bioactive materials·2025
Same author

Two decades of continuous progresses and breakthroughs in the field of bioactive ceramics and glasses driven by CICECO-hub scientists.

Bioactive materials·2024
Same author

Multidrug-Resistant Shigella sonnei Bacteremia among Persons Experiencing Homelessness, Vancouver, British Columbia, Canada.

Emerging infectious diseases·2023

Area of Science:

  • Organic Chemistry
  • Crystallography
  • Natural Products Chemistry

Background:

  • Eunicin acetate is a known cembranolide natural product.
  • Spirocyclic compounds often exhibit unique chemical properties and biological activities.

Purpose of the Study:

  • To determine the precise three-dimensional structure of a novel pyrazoline derivative of eunicin acetate.
  • To investigate the structural impact of spiro substitution on the cembranolide framework.

Main Methods:

  • X-ray crystallography was employed for crystal structure determination.
  • Detailed analysis of bond lengths, bond angles, and molecular conformation was performed.

Main Results:

  • The crystal structure of spiro [¿3a,4,5,6,7,8,11,12,13,14,15,15a-dodecahydro-6,10,14-trimet hyl-2-oxo-5, 15-epoxy-3H-cyclotetradeca-[b]furan¿-3,3'-1'-pyrazoline]-6-yl acetate (C23H34N2O5) was established.

Related Experiment Videos

  • Spiro substitution led to elongation of bonds in the lactone ring and shortening of the carbonyl bond.
  • The cembranolide skeleton exhibited a slightly more bent conformation compared to eunicin.

    • Conclusions:

    • The study provides a detailed structural characterization of a novel pyrazoline derivative of eunicin acetate.
    • The findings highlight the significant structural modifications induced by spiro substitution in cembranolides.
    • This structural insight could inform future studies on the synthesis and bioactivity of related compounds.