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Related Experiment Videos

Mucous glands in the developing human rhinopharynx

M Tos

    The Laryngoscope
    |June 1, 1977
    PubMed
    Summary

    Rhinopharyngeal glands develop rapidly from the 11th week, reaching over 1,100 by the 23rd week. Their distribution and density vary across the rhinopharynx, with implications for its function.

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    Area of Science:

    • Embryology
    • Anatomy
    • Histology

    Background:

    • The rhinopharynx's glandular structure is crucial for its physiological functions.
    • Understanding the developmental trajectory of these glands is essential for comprehending nasopharyngeal health.

    Purpose of the Study:

    • To investigate the developmental timeline and spatial distribution of glands in the human rhinopharynx during fetal and premature stages.
    • To characterize the growth, spread, and density of these glands.

    Main Methods:

    • Whole-mount staining techniques were applied to the entire rhinopharyngeal mucosa of 42 fetuses and premature infants.
    • Detailed analysis of gland development, growth, spread, distribution, situation, and size was performed.

    Main Results:

    • Gland development commences at the 11th week below the tubal orifice and spreads throughout the rhinopharynx.
    • Glandular count increases by approximately 60-70 glands weekly, reaching 1,100-1,200 by the 23rd week.
    • Gland density and size are maximal in specific regions, including Rosenmüller's recess and the salpingopharyngeal fold.

    Conclusions:

    • The formation of rhinopharyngeal glands is largely complete by the 23rd week of gestation.
    • The study provides a detailed map of gland distribution and density, crucial for understanding rhinopharyngeal physiology and pathology.

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