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Combined treatment with enuresis alarm and desmopressin for nocturnal enuresis
1Department of Paediatrics and Child Health, St James's University Hospital, Leeds, UK.
Insights
Combining desmopressin with enuresis alarms significantly improves treatment outcomes for children with nocturnal enuresis, especially those with severe symptoms or behavioral issues.
Area of Science:
- Pediatrics
- Urology
- Sleep Medicine
Background:
- Nocturnal enuresis, or bedwetting, affects many children.
- Effective treatments are crucial for improving quality of life.
Purpose of the Study:
- To evaluate the efficacy of combining intranasal desmopressin with enuresis alarms for treating nocturnal enuresis in children.
Main Methods:
- A controlled trial involving 71 children with nocturnal enuresis.
- Two matched groups: one using enuresis alarms with desmopressin, the other using alarms alone.
- Treatment duration for desmopressin was up to 6 weeks.
Main Results:
- Both groups showed improvement, averaging 2.3 dry nights per week during observation.
- The desmopressin and alarm group achieved significantly more dry nights per week (6.3) compared to the alarm-only group (4.8) at treatment end.
- A higher number of children in the combined treatment group became reliably dry.
Conclusions:
- The combination of desmopressin and enuresis alarms is a highly effective treatment for nocturnal enuresis.
- This combined approach is particularly beneficial for children with severe wetting, family history, or behavioral challenges.
Abstract:
Seventy-one children with nocturnal enuresis were enrolled in a controlled trial. The children were allocated to two matched groups. Children in both groups used an enuresis alarm until the end of treatment. Children in the first group were treated with 40 micrograms of intranasal desmopressin (Desmospray) for up to 6 weeks at the start of treatment with the alarm. During the observation period treatment there were 2.3 dry nights per week in both groups. At the end of treatment there was a significant difference in the mean number of dry nights per week between the two groups (6.3 in the alarm and desmopressin group and 4.8 in the alarm group) and also in the number of children becoming reliably dry. The combination of desmopressin and alarm was particularly helpful for children with severe wetting and those with family and behavioural problems.