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Effect of occlusion on human skin
H Matsumura1, K Oka, K Umekage
1Third Research Group of Japanese Society for Cutaneous Health, Kyoto, Japan.
Contact Dermatitis
|October 1, 1995
Summary
Simple skin occlusion can lead to deeper skin furrows, especially under humid conditions. Prolonged exposure to sweat due to occlusion may irritate the skin, acting as a primary irritant.
Area of Science:
- Dermatology
- Skin Physiology
Background:
- Skin occlusion is a common condition in various settings.
- Understanding occlusion's effects on skin morphology is crucial for preventing irritation.
Purpose of the Study:
- To investigate the morphological changes in skin surface due to simple occlusion.
- To determine the relationship between occlusion, environmental factors, and skin alterations.
Main Methods:
- Occlusion chambers were applied to upper arms for 24 hours.
- Skin surface morphology was analyzed using the nitrocellulose-replica method.
- Water vapor permeability of sealing films was varied to control internal humidity.
Main Results:
- Microscopic analysis revealed an increase in deepened skin furrows after occlusion.
- This effect was more pronounced with lower water vapor permeability films.
- Higher ambient temperature and humidity correlated with increased furrow depth.
Conclusions:
- Simple skin occlusion can induce microscopic changes, including deepened furrows.
- Occlusion, particularly under high humidity and temperature, may lead to skin irritation.
- Prolonged exposure to trapped sweat can act as a primary skin irritant.