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Hemolysis with the F21 hemopump
1Centre for Experimental Surgery and Anaesthesiology, Leuven, Belgium.
The International Journal of Artificial Organs
|July 1, 1995
Summary
Foreign bodies significantly increase free hemoglobin levels and impede hemopump function. Mechanical factors and pump disorders can also elevate plasma free hemoglobin, indicating potential issues with anticoagulation, renal function, or red blood cells.
Area of Science:
- Biomedical Engineering
- Cardiovascular Devices
Background:
- Elevated free hemoglobin is a concern in mechanical circulatory support.
- Understanding factors affecting hemoglobin integrity is crucial for device safety.
Purpose of the Study:
- To investigate the impact of mechanical factors on free hemoglobin release using an F21 hemopump cannula.
- To identify sources of free hemoglobin increase during mock circulation.
Main Methods:
- Testing mechanical factors including flow, rotary speed, and tube cross-section reduction.
- Introducing foreign materials into the hemopump system.
- Utilizing a mock circulation model with ox blood.
Main Results:
- Foreign bodies, particularly on the screw, significantly increased free hemoglobin.
- Hemopump flow was substantially reduced or stopped by small foreign materials on the screw.
- Elevated plasma free hemoglobin concentrations may indicate broader issues.
Conclusions:
- Mechanical factors, especially foreign material contamination, directly influence free hemoglobin levels.
- Hemopump performance is highly sensitive to foreign bodies.
- Further investigation into pump disorders, anticoagulation, renal function, and red blood cell status is warranted for elevated free hemoglobin.