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Association between hepatitis B virus and essential mixed cryoglobulinemia
The New England Journal of Medicine
|June 30, 1977
Summary
Essential mixed cryoglobulinemia often involves the liver. This study found significant evidence of hepatitis B virus infection in patient cryoprecipitates, suggesting a causal link.
Area of Science:
- Hepatology
- Virology
- Immunology
Background:
- Essential mixed cryoglobulinemia frequently presents with liver involvement.
- The role of hepatitis B virus (HBV) in this condition requires further investigation.
Purpose of the Study:
- To investigate the presence and significance of hepatitis B virus infection in patients with essential mixed cryoglobulinemia.
- To determine if HBV is implicated in the pathogenesis of essential mixed cryoglobulinemia.
Main Methods:
- Analysis of 25 serum specimens and 19 cryoprecipitates from 30 patients for hepatitis B surface antigen (HBsAg) and antibody.
- Electron microscopy of cryoprecipitates to identify HBV-characteristic particles.
Main Results:
- Hepatitis B virus markers (HBsAg or antibody) were detected in 74% of cryoprecipitates, a higher frequency than in serum.
- Electron microscopy confirmed the presence of hepatitis B virus particles in cryoprecipitates.
Conclusions:
- Hepatitis B virus infection is strongly associated with essential mixed cryoglobulinemia.
- The findings suggest that essential mixed cryoglobulinemia may be secondary to hepatitis B virus infection, warranting a reclassification of the syndrome.