Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypocellular acute myeloid leukemia: the Rochester (New York) experience

N Tuzuner1, C Cox, J M Rowe

  • 1Istanbul University, Cerrahpasa Medical Faculty, Turkey.

Hematologic Pathology
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Learning curves and breast cancer lymphatic mapping: institutional volume index.

The Journal of surgical research·2001
Same author

Encephalopathy associated with respiratory syncytial virus bronchiolitis.

Journal of child neurology·2001
Same author

Incidental discovery of pelvic cholelithiasis on diagnostic laparoscopy.

Surgical endoscopy·2001
Same author

Methylmercury and neurodevelopment: reanalysis of the Seychelles Child Development Study outcomes at 66 months of age.

JAMA·2001
Same author

Depression and self-reported functional status in older primary care patients.

The American journal of psychiatry·2001
Same author

A randomized, controlled trial of remacemide for motor fluctuations in Parkinson's disease.

Neurology·2001

Hypocellular acute leukemia (HAL) in older adults often presents with low white blood cell counts and increased marrow blasts. Despite challenging induction therapy, a significant remission rate was observed in this patient cohort.

Area of Science:

  • Hematology
  • Oncology

Background:

  • Hypocellular acute leukemia (HAL) is a rare subtype of acute myeloid leukemia.
  • Characterized by decreased cellularity in the bone marrow, it presents diagnostic challenges.

Purpose of the Study:

  • To review the clinical characteristics, diagnostic features, and treatment outcomes of patients with hypocellular acute leukemia.
  • To explore potential associations between specific morphological and immunophenotypic features and treatment response.

Main Methods:

  • Retrospective review of 14 patients diagnosed with hypocellular acute leukemia.
  • Analysis of peripheral blood and bone marrow morphology, FAB classification, immunophenotyping (flow cytometry), and treatment data.

Main Results:

  • Median age was 72 years; common features included severe granulocytopenia and increased marrow blasts.

Related Experiment Videos

  • FAB classification showed a predominance of M1, M2, and M6 subtypes. Trilineage dysplasia was observed in 5 cases.
  • Induction therapy (daunorubicin and cytosine arabinoside) achieved complete remission in 72.6% of patients, with a median survival of 10.5 months.

    • Conclusions:

    • Hypocellular acute leukemia in older adults can achieve significant remission rates with standard induction therapy.
    • Trilineage dysplasia and FAB M6 subtype may indicate a specific form of acute myeloid leukemia.
    • Further research is needed to optimize treatment strategies for this challenging leukemia subtype.