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Updated: Jul 30, 2026

Analysis of Cell Cycle Position in Mammalian Cells
Published on: January 21, 2012
Regulation of transcription by E2F1/DP1
K Martin1, D Trouche, C Hagemeier
1Wellcome/CRC Institute, University of Cambridge, UK.
Abstract:
The E2F1 transcription factor, in co-operation with DP1, controls the expression of several S-phase specific genes. This activity is most likely responsible for the oncogenic and S-phase inducing properties of E2F1, suggesting that this transcription factor plays a key role in regulating the cell cycle. The transcriptional activation functions of E2F1 are resident in a small C-terminal domain which can independently activate transcription. Here we review the protein-protein interactions which impinge upon and regulate this activation domain and put forward some models on their mechanism of action.
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