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Related Experiment Videos

Intestinal triacylglycerol storage pool size changes under differing physiological conditions

P Nevin1, D Koelsch, C M Mansbach

  • 1Department of Medicine, University of Tennessee, Memphis 38163, USA.

Journal of Lipid Research
|November 1, 1995
PubMed
Summary

Intestinal triacylglycerol storage varies inversely with lymphatic lipid output efficiency. Factors like phosphatidylcholine and bile diversion significantly impact this crucial fat absorption pathway.

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Area of Science:

  • Gastroenterology
  • Lipid Metabolism
  • Cellular Biology

Background:

  • Intestinal triacylglycerol (TAG) is primarily transported via the portal vein, not exclusively in chylomicrons.
  • The size of the intestinal mucosal TAG storage pool is influenced by physiological conditions.

Purpose of the Study:

  • To investigate how varying physiological conditions affect the size of the intestinal mucosal TAG storage pool.
  • To understand the relationship between lymphatic lipid output and mucosal TAG storage.

Main Methods:

  • Four groups of rats underwent intraduodenal infusion for 4 hours.
  • Infusions included fasting, trioleoylglycerol (TAG), TAG with phosphatidylcholine, and bile-diverted TAG.
  • Quantification of TAG in the intestinal mucosa was performed.

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Main Results:

  • Mucosal TAG content increased from fasted to bile-diverted groups (A > B > C > D).
  • The TAG storage pool was smallest in fasted and phosphatidylcholine-infused groups (A, C) and largest in TAG-infused and bile-diverted groups (B, D).
  • Trioleoylglycerol percentage in mucosal TAG was higher in groups B and D compared to A.

Conclusions:

  • Intestinal mucosal TAG storage pool size is inversely related to lymphatic lipid output efficiency.
  • Phosphatidylcholine enhances lymphatic lipid output, reducing mucosal TAG storage.
  • Bile diversion impairs lipid output, increasing mucosal TAG storage.