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Related Experiment Videos

Renal and neuronal abnormalities in mice lacking GDNF

M W Moore1, R D Klein, I Fariñas

  • 1Department of Molecular Biology, Genentech, Inc., South San Francisco, California 94080, USA.

Nature
|July 4, 1996
PubMed
Summary

Glial cell-line derived neurotrophic factor (GDNF) is crucial for developing enteric, sympathetic, and sensory neurons, along with the renal system. However, GDNF is not essential for central nervous system catecholaminergic neurons.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genetics

Background:

  • Glial cell-line derived neurotrophic factor (GDNF) is a known survival factor for various neuronal populations.
  • GDNF is considered a potential therapeutic agent for neurodegenerative diseases like Parkinson's disease.
  • Its physiological role in neuronal development and survival in vivo is well-established.

Purpose of the Study:

  • To investigate the specific roles of GDNF in the development and survival of different neuronal cell types and organ systems.
  • To determine if GDNF is essential for catecholaminergic neurons in the central nervous system (CNS).

Main Methods:

  • Generation and analysis of GDNF-deficient mice at postnatal day 0 (P0).
  • Assessment of neuronal populations including dorsal root ganglion, sympathetic, nodose, hindbrain noradrenergic, and midbrain dopaminergic neurons.

Related Experiment Videos

  • Evaluation of the enteric nervous system (ENS), ureters, and kidneys in GDNF-deficient mice.

    • Main Results:

    • GDNF-deficient mice showed deficits in dorsal root ganglion, sympathetic, and nodose neurons.
    • No deficits were observed in hindbrain noradrenergic or midbrain dopaminergic neurons.
    • GDNF-deficient mice completely lacked the enteric nervous system (ENS), ureters, and kidneys.

    Conclusions:

    • GDNF plays a critical role in the development and/or survival of enteric, sympathetic, and sensory neurons.
    • GDNF is essential for the proper development of the renal system (ureters and kidneys).
    • GDNF is not essential for the development or survival of catecholaminergic neurons in the CNS.