[Effect of extreme conditions on succinate oxidation in rat brain mitochondria]

Emergencies which were different in origin, but identical in the magnitude of pathogenic action on the brain, such as 3.5-hour cerebral circulatory ischemia found 49-hour restriction stress, induced the the same brain mitochondrial responses in Wistar rats. Two types of responses in organelles were identified: (1) that wherein there were lower succinate oxidation rates than those in the control (sham = operated and intact animals) and diverted effects on succinate dehydrogenase activators; (2) that wherein there was accelerated succinate oxidation and persisted stimulating effects of enzyme activators. A relationship was shown between the type of responses and the degree of succinate dehydrogenase inhibition induced by emergencies.