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Updated: Jul 15, 2026

Glycan Node Analysis: A Bottom-up Approach to Glycomics
Published on: May 22, 2016
[Role of glyoxalases and methylglyoxal in cell proliferation and differentiation]
D Piskorska1, R Grabowska-Bochenek
1Katedra i Zakład Biochemii i Chemii Slaaskiej Akademii Medycznej w Katowicach.
Abstract:
The glyoxalase system catalyses the conversion of methylglyoxal (and other 2-ketoaldehydes) to D-lactic acid via the intermediate S-D-lactoylglutathione. It comprises two enzymes, glyoxalases I and glyoxalases II, and catalytic amount to reduced glutathione. Methylglyoxal inhibits cell growth, while the glyoxalase system by breaking down methylglyoxal may act as a promoter of cell growth. Inhibitors of glyoxalases may serve as possible therapeutic agents against cancer by virtue of their ability to elevate the level of methylglyoxal in the body.
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