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Nicotine self-administration in rats

E C Donny1, A R Caggiula, S Knopf

  • 1Department of Psychology, University of Pittsburgh, PA 15260, USA.

Psychopharmacology
|December 1, 1995
PubMed
Summary
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Rats self-administered intravenous nicotine, demonstrating stable drug-maintained behavior. This reliable model aids in studying nicotine

Area of Science:

  • Pharmacology
  • Neuroscience
  • Behavioral Science

Background:

  • Self-administration models are crucial for understanding drug-maintained behavior.
  • Previous research by Corrigall and Coen established nicotine self-administration models.

Purpose of the Study:

  • To replicate and validate the findings of Corrigall and Coen regarding nicotine self-administration.
  • To establish a reliable animal model for studying the behavioral effects of nicotine.

Main Methods:

  • Male Sprague-Dawley rats, initially trained on food reinforcement, were used.
  • Rats underwent intravenous self-administration of nicotine bitartrate (0.03 mg/kg, free base).
  • Extinction and reacquisition phases were implemented using saline and nicotine, respectively.

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Main Results:

  • Stable and high rates of nicotine self-administration were acquired by the rats.
  • A lower dose (0.003 mg/kg) resulted in decreased responses, infusions, and intake.
  • A higher dose (0.06 mg/kg) led to increased nicotine intake.

Conclusions:

  • The study successfully replicated nicotine self-administration in rats.
  • This self-administration model offers a dependable alternative to experimenter-administered nicotine for research.
  • The model is suitable for investigating the mechanisms underlying nicotine's effects on behavior.