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[Vigilance-decreasing effects of 2 plant-derived sedatives]
U Gerhard1, N Linnenbrink, C Georghiadou
1Psychologische Abteilung, Psychiatrische Universitätsklinik, Basel.
Praxis
|April 9, 1996
Summary
Valerian-based sleep remedies showed no significant residual sedative effects, unlike flunitrazepam. Plant-based options are safer alternatives for drivers, though slight performance impairment may occur initially.
Area of Science:
- Pharmacology
- Neuroscience
- Herbal Medicine
Background:
- Plant-based sedatives like valerian are increasingly used for sleep.
- Concerns exist regarding potential vigilance impairment from these remedies.
- Limited controlled studies compare their effects to benzodiazepines.
Purpose of the Study:
- To assess residual sedative effects of valerian and hops vs. flunitrazepam and placebo.
- To evaluate potential hazards for driving or operating machinery.
- To compare immediate sedative effects of plant preparations.
Main Methods:
- Controlled study with healthy volunteers.
- Single oral administration of valerian/hops, valerian-only, flunitrazepam, or placebo.
- Objective psychomotor performance tests and subjective well-being questionnaires.
- Assessment of acute and residual (hangover) effects.
Main Results:
- Flunitrazepam caused significant objective and subjective performance impairment the next morning.
- Plant-based remedies showed no significant residual impairment; subjective well-being improved.
- Slight, transient vigilance impairment noted with plant remedies within hours of ingestion.
Conclusions:
- Recommended doses of valerian-based sleep remedies do not cause concerning residual sedative effects on vigilance or cognitive performance.
- Plant remedies are viable alternatives to benzodiazepines for drivers and machinery operators.
- Anticipate slight performance impairment in the first few hours after ingesting plant-based sleep aids.
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