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The aging immune system: primer and prospectus
1University of Michigan School of Medicine, University of Michigan Institute of Gerontology, Ann Arbor, 48109-0642, USA.
Science (New York, N.Y.)
|July 5, 1996
Abstract:
Changes in T lymphocyte populations underlie much of the age-related decline in the protective immune response. Aging leads to the replacement of virgin T cells by memory T cells and to the accumulation of cells with signal transduction defects. Studies of antibody gene assembly, accessory cell function, post-thymic T cell development, skewed selection of T cell receptor repertoire, and the clinical concomitants of immune senescence will shed new light on the causes and consequences of age-dependent immune failure.