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[Anaphylactic reaction to protamine in cardiovascular surgery]
1Kardiovaskulární a transplantacní chirurgie VFN, Praha.
Rozhledy V Chirurgii : Mesicnik Ceskoslovenske Chirurgicke Spolecnosti
|September 1, 1995
Summary
Protamine administration can cause serious anaphylactic reactions, including life-threatening drops in blood pressure. This case study demonstrates successful management using colloid solutions, adrenaline, and solumedrol.
Area of Science:
- Cardiology
- Anesthesiology
- Immunology
Background:
- Protamine sulfate is routinely used in cardiovascular surgery to reverse heparin anticoagulation.
- Adverse hemodynamic reactions to protamine are common, ranging from mild to severe, life-threatening anaphylaxis.
- The incidence of serious protamine reactions is estimated between 0.13% and 4%.