[The index of PSA age vs PSA density. 2 new instruments in the detection of prostatic carcinoma]

A prospective study was designed to get to know the reliability of PSA density and PSA age index as tools in the diagnostic approach for prostate carcinoma. It was noted that PSA age index is more susceptible than PSA density to diagnose prostate cancer. We noted also that up to 80% of patients with prostate cancer and intermediate PSA levels have PSA density < 0.15 and that, according to current protocols biopsy should not have been performed. It was concluded that the value of PSA age index is at least equal to PSA density, but it eradicates the subjectivity introduced by this data because of the need of measuring prostate volume. We believe that in the future it may be indicated to perform biopsies at PSA levels above 4 ng/ml, and it may be necessary to decrease PSa normal density levels down to 0.1 or less.