Sjögren's syndrome in children

Area of Science:

• Pediatric Rheumatology
• Autoimmune Diseases

Background:

• Sjögren's syndrome is an autoimmune disorder primarily affecting exocrine glands.
• Its presentation in children is uncommon and lacks extensive documentation.

Observation:

• This study focuses on two pediatric cases of Sjögren's syndrome.
• Both cases were associated with systemic lupus erythematosus.

Findings:

• Detailed clinical features and laboratory results are presented.
• Diagnostic investigations included minor salivary gland biopsy, parotid scintigraphy, and renal biopsy.
• Specific immunological and organ-specific manifestations were observed.

Implications:

• Enhances understanding of childhood Sjögren's syndrome, particularly when co-occurring with lupus.
• Highlights the importance of comprehensive diagnostic workups in pediatric autoimmune cases.
• Contributes to the limited literature on pediatric Sjögren's syndrome and its systemic associations.