Identification and antisense inhibition of Na-Ca exchange in renal epithelial cells
K E White1, F A Gesek, P A Friedman
1Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755-3835, USA.
Annals of the New York Academy of Sciences
|April 15, 1996
Abstract:
In summary, DCT cells express multiple isoforms of the Na-Ca exchanger and exhibit functional exchange, and antisense oligonucleotides to a downstream region of the exchanger transcript inhibit activity. These experiments provide direct evidence for Na-Ca exchange in DCT cells mediated by NACA2, NACA3, or NACA6.


