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Inherited disorders: the comparative picture

F W Nicholas1, P A Harper

  • 1Department of Animal Science, University of Sydney, New South Wales.

Australian Veterinary Journal
|February 1, 1996
PubMed
Summary
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Veterinarians can use Mendelian Inheritance in Man (MIM) and its online version (OMIM) to identify homologous human disorders for novel animal diseases. Consulting comparative databases aids in diagnosing inherited animal conditions and advancing veterinary research.

Area of Science:

  • Veterinary Medicine
  • Genetics
  • Comparative Biology

Background:

  • Novel familial disorders in animals present diagnostic challenges for veterinarians.
  • Identifying homologous human conditions can provide valuable insights into animal diseases.
  • Existing resources for comparative genetic information are increasingly accessible online.

Purpose of the Study:

  • To guide veterinarians in diagnosing novel animal familial disorders.
  • To promote the use of human genetic databases for comparative veterinary medicine.
  • To establish a framework for hypothesizing and researching homology between human and animal disorders.

Main Methods:

  • Consulting Mendelian Inheritance in Man (MIM) and its online version, OMIM, for human inherited disorders.

Related Experiment Videos

  • Utilizing readily available comparative information sources on mice and domesticated species.
  • Leveraging World Wide Web resources for interspecies disorder comparisons.

    • Main Results:

    • MIM/OMIM can identify potential human homologs for animal familial disorders.
    • Comparative databases facilitate the exploration of genetic disease similarities across species.
    • The internet provides efficient access to these comparative resources.

    Conclusions:

    • Veterinarians should utilize MIM/OMIM and comparative databases for novel animal disorders.
    • Referencing MIM numbers in publications aids in testing homology hypotheses.
    • This approach supports advancing the understanding of inherited diseases in veterinary medicine.