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Bone mass in Parkinson's disease: a study with three methods

M Revilla1, G de la Sierra, F Aguado

  • 1Department of Medicine, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, E-28801 Spain.

Calcified Tissue International
|May 1, 1996
PubMed
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Parkinson's disease (PD) patients exhibit reduced bone mass, particularly males. Bone density changes in PD may vary by sex and measurement method, with higher osteopenia prevalence in female PD patients.

Area of Science:

  • Bone Metabolism and Aging
  • Neurology and Movement Disorders

Background:

  • Osteopenia is increasingly reported in Parkinson's disease (PD) patients.
  • Previous findings on bone mass in PD patients are conflicting, potentially due to methodological differences.

Purpose of the Study:

  • To investigate bone mass and related biochemical markers in Parkinson's disease patients.
  • To compare bone parameters between PD patients and age/sex-matched controls.
  • To explore potential sex-specific differences in bone changes associated with PD.

Main Methods:

  • Study included 52 PD patients and 80 controls, assessing total body bone mineral content (TBBMC), ultrasound bone velocity (UBV), and metacarpal radiogrammetry (CCT).
  • Serum levels of total alkaline phosphatase and tartrate-resistant acid phosphatase were measured.

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  • Statistical analyses compared bone parameters and biochemical markers between PD patients and controls, stratified by sex.

    • Main Results:

    • PD patients showed significantly increased serum alkaline phosphatase and tartrate-resistant acid phosphatase.
    • TBBMC was significantly lower in both male and female PD patients compared to controls.
    • UBV was significantly lower in male PD patients but not in females. Severe osteopenia was more prevalent in female PD patients (20.8%) than males (3.6%).

    Conclusions:

    • Bone mass alterations in Parkinson's disease patients are influenced by sex and the specific measurement techniques employed.
    • While TBBMC is reduced in both sexes, UBV differences suggest distinct bone changes in males.
    • The prevalence of osteopenia, particularly severe forms, appears higher in female PD patients, with no correlation to PD severity in this group.