Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Control strategies for tuberculosis epidemics: new models for old problems

S M Blower1, P M Small, P C Hopewell

  • 1Department of Epidemiology and Biostatistics, University of California San Francisco, CA 94143-1347, USA.

Science (New York, N.Y.)
|July 26, 1996
PubMed
Summary

Effective tuberculosis control requires lower treatment failure rates in developing nations. This study develops a framework to improve global tuberculosis eradication strategies and combat drug resistance.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rethinking latent TB? Think again.

IJTLD open·2024
Same author

Evaluating the use of educational videos to support the tuberculosis care cascade in remote Madagascar.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2020
Same author

Magnitude of <i>Mycobacterium tuberculosis</i> transmission among household and non-household contacts of TB patients.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2019
Same author

Interplay of strain and race/ethnicity in the innate immune response to M. tuberculosis.

PloS one·2018
Same author

Clinical and bacteriological characteristics associated with clustering of multidrug-resistant tuberculosis.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2017
Same author

Impact of Euro-American sublineages of <i>Mycobacterium tuberculosis</i> on new infections among named contacts.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2017

Area of Science:

  • Epidemiology
  • Infectious Disease Control
  • Mathematical Modeling

Background:

  • Tuberculosis (TB) remains a leading cause of adult mortality globally from infectious diseases.
  • Despite being preventable and curable, TB control strategies require refinement for optimal impact.
  • Suboptimal control programs may inadvertently drive the evolution of drug-resistant tuberculosis.

Purpose of the Study:

  • To develop a theoretical framework for designing effective tuberculosis control strategies.
  • To assess treatment levels for TB eradication and the impact of non-eradicating control measures.
  • To evaluate global TB control goals and suggest improvements for public health interventions.

Main Methods:

  • Development of a theoretical framework for TB control strategy design.

Related Experiment Videos

  • Application of the framework to analyze eradication scenarios and non-eradicating control effects.
  • Extension of the theory to model the evolution of drug resistance.
  • Definition of a new evaluation criterion for control strategy assessment.

    • Main Results:

    • The framework allows determination of optimal treatment levels for TB eradication.
    • Analysis reveals how suboptimal control programs contribute to drug resistance.
    • A novel evaluation criterion is proposed to enhance control strategy effectiveness.
    • Lower treatment failure rates are essential in developing countries for effective TB control.

    Conclusions:

    • A theoretical framework can guide the design of more effective tuberculosis control strategies.
    • Addressing treatment failure rates, particularly in developing countries, is critical for global TB eradication.
    • The study provides insights into optimizing interventions to combat tuberculosis and prevent drug resistance.