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Serine phosphorylation, chromosomal localization, and transforming growth factor-beta signal transduction by human
R J Lechleider1, M P de Caestecker, A Dehejia
1Laboratory of Chemoprevention, NCI, National Institutes of Health, Bethesda, Maryland 20892-5055. USA.
Abstract:
The transforming growth factor-beta (TGF-beta) superfamily regulates a multitude of cellular and developmental events. TGF-beta family ligands signal through transmembrane serine/threonine kinase receptors whose downstream effectors are largely unknown. Using genetic data from the fruit fly, we have identified a downstream effector of TGF-beta-induced signaling. TGF-beta signaling protein-1 (BSP-1) is rapidly phosphorylated in response to TGF-beta. Localization of bsp-1 to chromosome 4q28 suggests a role in carcinogenesis. These data suggest that BSP-1 is the prototype of a new class of signaling molecules.