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Methadone salts. Part 1: preparation and identification

N H Choulis, B S Sandhu, L Abellana-Intaphan

    Die Pharmazie
    |March 1, 1977
    PubMed
    Summary

    Two new methadone salts, methadone-alpha-naphthalenesulfonate and methadone-o-benzoyl-benzoate, were successfully synthesized. Their chemical structures were confirmed using thin-layer chromatography (t.l.c.) and infrared (IR) spectroscopy.

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    Area of Science:

    • Pharmaceutical Chemistry
    • Organic Synthesis

    Background:

    • Methadone is a synthetic opioid used for pain relief and opioid dependence treatment.
    • Development of novel salt forms can improve drug properties like solubility and stability.

    Purpose of the Study:

    • To synthesize and characterize two new methadone salts: methadone-alpha-naphthalenesulfonate and methadone-o-benzoyl-benzoate.
    • To confirm the identity and purity of the synthesized compounds.

    Main Methods:

    • Synthesis of methadone salts via acid-base reaction.
    • Confirmation of compound identity using thin-layer chromatography (t.l.c.).
    • Characterization of functional groups using infrared (IR) spectroscopy.

    Main Results:

    • Successful preparation of methadone-alpha-naphthalenesulfonate.
    • Successful preparation of methadone-o-benzoyl-benzoate.
    • T.l.c. and IR spectroscopy confirmed the formation and structure of both synthesized salts.

    Conclusions:

    • The study successfully prepared and confirmed two novel methadone salts.
    • The synthetic methods and characterization techniques provide a basis for further research into these compounds.
    • These new salts may offer alternative formulations for methadone with potentially improved pharmacokinetic profiles.

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