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No difference found between winter- and non-winter-born schizophrenic cases

M A Roy1, M Flaum, N C Andreasen

  • 1Department of Psychiatry, University of Iowa Hospitals and Clinics, Iowa City, USA.

Schizophrenia Research
|November 1, 1995
PubMed
Summary
This summary is machine-generated.

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Investigating winter birth in schizophrenia revealed no distinct clinical or biological differences between winter-born (WBS) and non-winter born (NWBS) individuals. This suggests the WBS distinction has limited power for identifying schizophrenia subtypes.

Area of Science:

  • Psychiatry
  • Neuroscience
  • Genetics

Background:

  • Schizophrenia subtypes are poorly understood.
  • Winter birth is hypothesized as an environmental risk factor for schizophrenia.
  • Distinguishing winter-born schizophrenic cases (WBS) may identify etiologic subtypes.

Purpose of the Study:

  • To empirically test the validity of the winter-born (WBS) vs. non-winter born (NWBS) distinction.
  • To compare WBS and NWBS groups across clinical and biological variables.

Main Methods:

  • Assessed DSM-III-R schizophrenic, schizoaffective, and schizophreniform subjects.
  • Utilized Comprehensive Assessment of Symptoms and History, neurological exam, neuropsychological battery (IQ, CPT), and MRI.
  • Defined WBS and NWBS using five different criteria.

Related Experiment Videos

Main Results:

  • No significant differences were found between WBS and NWBS groups on any of the 23 assessed variables.
  • The proposed WBS/NWBS distinction did not differentiate patient groups.

Conclusions:

  • The WBS/NWBS distinction has limited utility in identifying distinct etiologic subtypes of schizophrenia.
  • Identifying environmental risk factors in schizophrenia requires better methods than simply defining winter birth.