Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does re-exposure to mismatched HLA antigens decrease renal re-transplant allograft survival?

A C Farney1, A J Matas, H J Noreen

  • 1Department of Surgery, University of Minnesota, Minneapolis 55455, USA.

Clinical Transplantation
|April 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effect of peri-transplant plasmapheresis in the prevention of recurrent FSGS.

Pediatric transplantation·2018
Same author

Genome-wide association study identifies the common variants in CYP3A4 and CYP3A5 responsible for variation in tacrolimus trough concentration in Caucasian kidney transplant recipients.

The pharmacogenomics journal·2017
Same author

Renal Consequences of Diabetes After Kidney Donation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2017
Same author

The impact of recipient BKV shedding before transplant on BKV viruria, DNAemia, and nephropathy post-transplant: A prospective study.

Pediatric transplantation·2017
Same author

The Living Donor Collective: A Scientific Registry for Living Donors.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2017
Same author

Defining the Tipping Point in Surgical Performance for Laparoscopic Donor Nephrectomy Among Transplant Surgery Fellows: A Risk-Adjusted Cumulative Summation Learning Curve Analysis.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016
Same journal

Incidence and Impact of RAS-Like Opacities During Preserved Lung Function After Lung Transplantation.

Clinical transplantation·2026
Same journal

Sequential Donation: Evaluating Safety and Quality of Life of Living Donors.

Clinical transplantation·2026
Same journal

Pretransplant Malnutrition Risk Components are Associated With Adverse Outcomes After Simultaneous Pancreas and Kidney and Solitary Pancreas Transplantation.

Clinical transplantation·2026
Same journal

Feasibility, Safety and Outcomes of Early Mobilization in the ICU Following Lung Transplantation: A Scoping Review.

Clinical transplantation·2026
Same journal

Randomized Controlled Trial of a Digital Intervention (KidneyTIME) to Promote Live Donor Kidney Transplantation.

Clinical transplantation·2026
Same journal

Arterio-Enteric Fistula Arising From a Residual Transplant Renal Artery Stump 20 Years After Transplant Nephrectomy.

Clinical transplantation·2026
See all related articles

Kidney retransplant outcomes are similar whether or not the donor shares Human Leukocyte Antigen (HLA) mismatches with the previous transplant. This suggests routine HLA matching policies may not need exceptions for kidney retransplants.

Area of Science:

  • Nephrology
  • Immunology
  • Transplantation Science

Background:

  • Kidney retransplants typically have lower graft function rates compared to primary transplants.
  • Previous exposure to shared Human Leukocyte Antigen (HLA) antigens may trigger an anamnestic response, potentially impacting retransplant success, though existing literature presents conflicting findings.

Purpose of the Study:

  • To evaluate the impact of shared Human Leukocyte Antigen (HLA) mismatches with the prior donor on kidney retransplant graft survival.
  • To determine if kidney retransplant recipients benefit from avoiding donors with Human Leukocyte Antigen (HLA) mismatches previously encountered.

Main Methods:

  • Analysis of 420 kidney retransplants at the University of Minnesota, assessing Human Leukocyte Antigen (HLA) information.
  • Categorization of retransplants into two groups: 87 sharing at least one Human Leukocyte Antigen (HLA) mismatch with the previous donor and 333 without shared mismatches.

Related Experiment Videos

  • Life-table analysis was used to calculate patient and graft survival rates, with significance determined by the Lee-Desu statistic.

    • Main Results:

    • No statistically significant difference in patient or kidney graft survival rates was observed between retransplants with and without shared Human Leukocyte Antigen (HLA) mismatches (p >= 0.41).
    • At two years post-transplantation, graft functioning rates were comparable: 70% for cadaveric grafts with shared mismatches versus 61% without, and 71% for living donor grafts with shared mismatches versus 78% without.

    Conclusions:

    • The likelihood of a successful kidney retransplant outcome is not influenced by the presence of Human Leukocyte Antigen (HLA) mismatches shared with the previous donor.
    • Current findings support that exceptions to standard Human Leukocyte Antigen (HLA) matching protocols are not necessary for kidney retransplants.