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Hyponatraemia and hiccups

J George1, K Thomas, L Jeyaseelan

  • 1Christian Medical College, Tamil Nadu, India.

The National Medical Journal of India
|May 1, 1996
PubMed
Summary
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Low serum sodium (hyponatremia) is strongly linked to hiccups in hospitalized patients. This association, particularly with severe hiccups, suggests a potential cause and effect, aiding in diagnosis and treatment.

Area of Science:

  • Clinical Medicine
  • Nephrology
  • Neurology

Background:

  • Hiccups are a common symptom in patients with hyponatremia.
  • The association between hyponatremia and hiccups requires further investigation.

Purpose of the Study:

  • To evaluate the association between hyponatremia and hiccups in a hospital setting.
  • To determine if hyponatremia is an independent risk factor for hiccups.

Main Methods:

  • A case-control study was conducted with 50 patients who developed hiccups.
  • Patients were matched with controls based on age and sex.
  • Hiccup severity was graded daily for up to 7 days.

Main Results:

  • A significant independent association was found between hyponatremia and hiccups.

Related Experiment Videos

  • For every 10 mEq/L reduction in serum sodium, the risk of hiccups increased 17-fold.
  • Renal failure was another significant determinant of hiccups (odds ratio = 128).
  • A dose-response relationship was observed between hyponatremia severity and hiccup severity.

    • Conclusions:

    • Hyponatremia is strongly and independently associated with hiccups in hospitalized patients.
    • The observed dose-response relationship suggests a potential causative link.
    • Awareness of this association is crucial for diagnosis and management, especially where serum sodium measurement is challenging.