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[T1G3 bladder tumors: our experience]

S Pagano1, F Franzoso, F Pachera

  • 1Divisione di Urologia, Ospedale Niguarda Cà Granda, Milano.

Archivio Italiano Di Urologia, Andrologia : Organo Ufficiale [Di] Societa Italiana Di Ecografia Urologica E Nefrologica
|February 1, 1996
PubMed
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Superficial T1 Grade 3 bladder carcinoma has a high progression risk. Early cystectomy offers the best survival rates for these patients, outperforming other treatments.

Area of Science:

  • Urology
  • Oncology

Background:

  • T1 Grade 3 bladder carcinoma is a superficial tumor type with a significant risk of progression (50-70%).
  • Tumor grade is the primary prognostic factor, prompting research into additional biological markers.

Purpose of the Study:

  • To evaluate treatment outcomes for T1 Grade 3 bladder tumors.
  • To compare the efficacy of different therapeutic strategies, including endoscopic follow-up, early cystectomy, chemotherapy, and radiotherapy.

Main Methods:

  • 41 patients with T1G3 bladder tumors underwent initial transurethral resection (TUR) followed by a staging TUR two months later.
  • Subsequent treatments varied: endoscopic follow-up (15 patients), early cystectomy (7 patients), adjuvant chemotherapy (12 patients), and radiotherapy (6 patients).

Main Results:

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  • High progression rates were confirmed, with some cases advancing to higher stages or developing metastatic disease.
  • Early cystectomy demonstrated superior survival rates compared to other treatment modalities, excluding cases with early metastases.
  • Adjuvant chemotherapy showed poor results for recurrence but good results for progression percentages.

Conclusions:

  • T1 Grade 3 bladder carcinoma necessitates careful management due to its high progression risk.
  • Early cystectomy appears to be the most effective treatment for improving survival in these patients.
  • Further research is needed to optimize treatment strategies and improve outcomes for superficial bladder cancers.