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Glutamine

J C Hall1, K Heel, R McCauley

  • 1University Department of Surgery, Royal Perth Hospital, Western Australia, Australia.

The British Journal of Surgery
|March 1, 1996
PubMed
Summary
This summary is machine-generated.

Glutamine, a conditionally essential amino acid, supports nitrogen transport and gut barrier function. Supplementation may improve nitrogen balance and conserve muscle during metabolic stress.

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Area of Science:

  • Biochemistry
  • Physiology
  • Nutrition Science

Background:

  • Glutamine is the most abundant circulating amino acid, crucial for cell metabolism and nitrogen transport.
  • It's a primary fuel for rapidly dividing cells.
  • Deficiency can occur during metabolic stress, leading to its classification as conditionally essential.

Purpose of the Study:

  • To review the role of glutamine in metabolic stress.
  • To examine the evidence for glutamine's benefits in nitrogen homeostasis, muscle conservation, and gut barrier function.
  • To discuss clinical evidence for glutamine supplementation in nutritional support.

Main Methods:

  • Literature review of animal models and clinical studies.
  • Analysis of glutamine's metabolic functions.

Related Experiment Videos

  • Evaluation of clinical trial data on glutamine supplementation.

    • Main Results:

    • Animal models show glutamine provision improves nitrogen homeostasis and conserves skeletal muscle.
    • Evidence suggests glutamine enhances intestinal barrier function.
    • Clinical data supports the inclusion of glutamine in nutritional regimens.

    Conclusions:

    • Glutamine is vital for cellular function and metabolic homeostasis.
    • Supplementation with glutamine shows promise in clinical settings, particularly during metabolic stress.
    • Further research supports its role in nutritional therapy.