Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Radical surgery for advanced gallbladder carcinoma

M Miyazaki1, H Itoh, S Ambiru

  • 1First Department of Surgery, School of Medicine, Chiba University, Japan.

The British Journal of Surgery
|April 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The impact of earlier intervention by an antimicrobial stewardship team for specific antimicrobials in a single weekly intervention.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases·2018
Same author

Apolipoprotein C-1 maintains cell survival by preventing from apoptosis in pancreatic cancer cells.

Oncogene·2007
Same author

Isolation and characterization of native Cry j 3 from Japanese cedar (Cryptomeria japonica) pollen.

Allergy·2007
Same author

RhoC is essential for TGF-beta1-induced invasive capacity of rat ascites hepatoma cells.

Biochemical and biophysical research communications·2006
Same author

Ubiquitin-dependent degradation of SnoN and Ski is increased in renal fibrosis induced by obstructive injury.

Kidney international·2006
Same author

[Experiment to establish the therapeutic dosage and administration term of macrolide antibiotics using the Explant Culture Method for human nasal mucosa].

The Japanese journal of antibiotics·2003

Aggressive surgery for advanced gallbladder carcinoma, particularly Type I tumors involving the liver, improves long-term survival. Radical procedures offer better outcomes than non-curative resections for these challenging cases.

Area of Science:

  • Oncology
  • Surgical Oncology
  • Gastroenterology

Background:

  • Advanced gallbladder carcinoma presents significant surgical challenges.
  • Involvement of adjacent organs complicates treatment and prognosis.

Purpose of the Study:

  • To evaluate the outcomes of aggressive surgical management for advanced gallbladder carcinoma.
  • To assess the impact of adjacent organ involvement on surgical resectability and survival.

Main Methods:

  • Retrospective analysis of 44 patients with advanced gallbladder carcinoma (pT3/pT4).
  • Surgical procedures included extended hepatic resection, bile duct resection, pancreaticoduodenectomy, gastrointestinal resection, and portal vein resection/reconstruction.
  • Patients were classified into four types based on adjacent organ involvement (hepatic, bile duct, both, or gastrointestinal).

Related Experiment Videos

Main Results:

  • Curative resection was achieved in 14/15 patients with Type I (hepatic involvement) tumors versus 7/26 with Type III (hepatic and bile duct involvement) tumors (P < 0.0001).
  • Surgical mortality was 2/15 for Type I and 7/26 for Type III tumors.
  • Long-term survival after curative resection was significantly better than after non-curative resection (P < 0.01).
  • Survival for Type I tumors after curative resection was significantly better than for other types (P < 0.05).

Conclusions:

  • A classification system based on adjacent organ involvement aids in surgical planning for advanced gallbladder carcinoma.
  • Radical surgical procedures for Type I tumors are associated with favorable outcomes.
  • Aggressive surgical management, when feasible, can improve survival in selected patients with advanced gallbladder carcinoma.