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Cardiac Stress Test Induced by Dobutamine and Monitored by Cardiac Catheterization in Mice
15:45

Cardiac Stress Test Induced by Dobutamine and Monitored by Cardiac Catheterization in Mice

Published on: February 10, 2013

Cardiovascular effects of dobutamine stress testing in women with suspected coronary artery disease

P Blomstrand1, J Engvall, E Swahn

  • 1Linköping Heart Centre, University Hospital, Sweden.

Heart (British Cardiac Society)
|May 1, 1996
PubMed

Insights

Dobutamine stress testing in women with suspected heart disease causes vasodilation and increased cardiac output. Hypotension can occur due to vasovagal responses or inadequate cardiac output increase.

Area of Science:

  • Cardiology
  • Hemodynamics
  • Vascular Physiology

Background:

  • Ischaemic heart disease diagnosis often involves stress testing.
  • Dobutamine stress testing is used to assess cardiac function.
  • Hypotension is a potential side effect of dobutamine stress testing.

Purpose of the Study:

  • Investigate hemodynamic responses during dobutamine stress testing in women.
  • Identify reasons for hypotension during dobutamine stress testing.

Main Methods:

  • 18 women (54-73 years) with suspected ischaemic heart disease underwent dobutamine infusion.
  • Doppler echocardiography and venous occlusion plethysmography were used.
  • Testing occurred 5-10 days post-unstable angina.

Main Results:

  • Dobutamine increased heart rate (49%) and cardiac output (59%).
  • Peripheral vascular resistance decreased significantly (total: 44%, leg: 26%).
  • Four patients experienced hypotension, linked to pronounced vasodilation or low cardiac output increase.

Conclusions:

  • Dobutamine causes significant peripheral vasodilation and increased cardiac output.
  • Hypotension can result from vasovagal reactions or insufficient cardiac output augmentation.
  • Disparate peripheral resistance changes may indicate baroreceptor-mediated responses.
Abstract

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