The hepatopulmonary syndrome. Effect of liver transplantation

The role of liver transplantation as a treatment for the hepatopulmonary syndrome (HPS) has had an evolving and controversial history. Although early experience was disappointing, more recent experience has documented resolution of HPS-associated hypoxemia after liver transplantation. This article reviews the history of liver transplantation for patients with the hepatopulmonary syndrome. In addition, we discuss the clinical features that have been considered to predict successful reversibility and the time frame over which reversal occurs. Despite this evolution of thought, many basic questions still remain.