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Related Experiment Videos

Is alpha-adrenoceptor blockade responsible for atropine flush?

K C Chang1, K H Hahn

  • 1Department of Pharmacology, College of Medicine, Gyeongsang National University, Chinju, South Korea.

European Journal of Pharmacology
|September 25, 1995
PubMed
Summary

Atropine can dilate skin blood vessels, causing flushing. This study reveals atropine directly blocks alpha-adrenoceptors, particularly at high doses, explaining this vascular response.

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Area of Science:

  • Pharmacology
  • Cardiovascular Physiology
  • Neuropharmacology

Background:

  • Atropine is known to cause cutaneous vasodilation (atropine flush), but the underlying mechanism remains unclear.
  • This vascular effect occurs with both toxic and occasional therapeutic doses of atropine.

Purpose of the Study:

  • To investigate the mechanism behind atropine-induced vasodilation.
  • To determine if atropine interacts with alpha-adrenoceptors involved in vascular contraction.

Main Methods:

  • Functional studies using isolated rat thoracic aortic rings contracted with norepinephrine, U46619, and KCl.
  • Binding studies using rat cerebral cortex homogenates to assess atropine's affinity for alpha-adrenoceptors.

Main Results:

Related Experiment Videos

  • Atropine relaxed norepinephrine-induced contractions but not those mediated by U46619 or KCl.
  • Atropine competitively antagonized phenylephrine at alpha-adrenoceptors (pA2 = 6.57).
  • Atropine demonstrated low-affinity displacement of [3H]prazosin from alpha-adrenoceptors in brain tissue.

Conclusions:

  • Atropine exhibits direct alpha-adrenoceptor blocking activity, especially at higher concentrations.
  • This alpha-adrenoceptor blockade likely contributes to the atropine flush phenomenon.