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[Infected bowel syndrome]

A Campanozzi1, O Borrelli, G Salvia

  • 1Dipartimento di Pediatria-Università degli Studi Federico II di Napoli, Italia.

La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics
|November 1, 1995
PubMed
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Small intestinal bacterial overgrowth (SIBO) involves excessive bacteria in the upper gut, causing malabsorption and pain. Diagnosis and treatment focus on identifying predisposing factors and using targeted antimicrobial therapy.

Area of Science:

  • Gastroenterology
  • Microbiology
  • Internal Medicine

Background:

  • Gut bacteria colonization starts at birth, influenced by host defenses like gastric acidity and motility.
  • Small intestinal bacterial overgrowth (SIBO) is characterized by high bacterial counts in the upper intestine, often anaerobes.

Purpose of the Study:

  • To describe the characteristics, predisposing conditions, diagnosis, and treatment of small intestinal bacterial overgrowth.

Main Methods:

  • Review of conditions predisposing to SIBO, including anatomic disorders and motility issues.
  • Discussion of diagnostic challenges and the role of jejunal aspirate cultures.
  • Evaluation of antimicrobial therapy and the importance of addressing underlying causes.

Main Results:

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  • SIBO frequently presents with steatorrhea, carbohydrate malabsorption, and abdominal pain.
  • Predisposing factors include surgical blind loops, strictures, short-gut syndrome, motility disorders, and reduced gastric acidity.
  • Quantitative jejunal aspirate cultures are the optimal diagnostic method.

Conclusions:

  • Antimicrobial therapy targeting anaerobes can be effective for SIBO.
  • The most effective treatment involves correcting the predisposing conditions that lead to bacterial overgrowth.