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Related Experiment Videos

Acute and chronic stroke: navigated spin-echo diffusion-weighted MR imaging

M P Marks1, A de Crespigny, D Lentz

  • 1Department of Radiology, Stanford University Medical Center, Stanford, CA 94305-5105, USA.

Radiology
|May 1, 1996
PubMed
Summary
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Phase-navigated spin-echo diffusion-weighted imaging aids early stroke diagnosis. This technique improves lesion visualization and helps differentiate acute from chronic cerebral infarction, with changes reversing after symptom resolution.

Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • Diffusion-weighted (DW) magnetic resonance (MR) imaging is crucial for diagnosing acute cerebral infarction.
  • Motion artifacts can degrade image quality and diagnostic accuracy in DW imaging.
  • Phase-navigated spin-echo (SE) sequences offer potential for motion correction.

Purpose of the Study:

  • To evaluate a phase-navigated SE motion-correction sequence for DW MR imaging in patients with cerebral infarction.
  • To assess the sequence's effectiveness in visualizing ischemic lesions and differentiating stroke types.

Main Methods:

  • Twenty-nine patients with stroke, transient ischemic attack, or reversible ischemic neurologic deficit underwent conventional T2-weighted fast SE and SE DW imaging.
  • Apparent diffusion coefficient (ADC) maps were constructed to quantify diffusion changes.

Related Experiment Videos

  • Imaging was performed using a standard head holder and padding.

    • Main Results:

    • DW images clearly depicted ischemic lesions, outperforming T2-weighted images.
    • Acute infarcts showed uniformly low ADC values (mean, 0.401x10(-5) cm2/sec) compared to controls (mean, 0.754x10(-5) cm2/sec).
    • Chronic infarcts exhibited supranormal ADC values (mean, 1.591x10(-5) cm2/sec) compared to controls (mean, 0.788x10(-5) cm2/sec).

    Conclusions:

    • Clinical phase-navigated SE DW imaging enhances early stroke diagnosis.
    • The technique aids in differentiating acute from chronic stroke.
    • Observed changes on DW images are reversible after symptom resolution.