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A model for cross-over trials evaluating therapeutic preferences
1Department of Medical Statistics, School of Computing Sciences, De Monfort University, Leicester, UK.
Statistics in Medicine
|February 28, 1996
Abstract:
A preference trial is a special form of cross-over trial where clinical conditions determine when patients change treatment, in a prescribed order. This can be modelled using a geometric distribution. The model can be simply fitted using standard logistic regression methodology. The procedure is applied to a trial studying the effects of bronchodilators in the treatment of chronic asthma.