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Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
Published on: July 6, 2013
Regulation of human cytomegalovirus by retinoic acid
1Department of Immunology, Scripps Research Institute, La Jolla, California, USA.
Abstract:
Human cytomegalovirus (HCMV) may opportunistically use retinoic acid (RA), a physiologically essential control molecule of cellular differentiation, to advance its own replication. At present, it is not clear whether RA stimulation of HCMV replication is exclusively a differentiation driven event. We report that exposure of permissively infected primary human foreskin fibroblast cells to RA transcriptionally activates the viral major immediate-early promoter (MIEP) and enhances the production of infectious particles. These experiments implicate a direct involvement of RA in modulating HCMV activation.
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